Survivorship of second-generation metal-on-metal primary total hip replacement. Arch Orthop Trauma Surg 132, 527–533 (2012).

Survivorship of second-generation metal-on-metal primary total hip replacement

Neuerburg, C., Impellizzeri, F., Goldhahn, J. et al.


Second generation metal-on-metal total hip replacements (THR) were introduced in the late 1980s and various studies reported conflicting data on their outcome.


Implant survival of 1,270 second-generation 28 mm metal-on-metal primary THR in 1,121 patients followed prospectively at a mean of 6.8 years postoperatively was evaluated retrospectively. The probability of survival at 10 years was estimated using the method of Kaplan and Meier, and relative risk factors including age, gender, BMI, type of implant fixation and component size were calculated using the Cox proportional-hazards model.


Sixty-three (5%) THRs were revised, these being 28 hips for aseptic loosening and 35 for reasons other than aseptic loosening. The probability of survival at 10 years, with revision for any reason as the endpoint, was 0.90 (95% confidence interval (CI) 0.86–0.94) for the THR as a whole, 0.91 (95% CI 0.87–0.95) for the cup, and 0.96 (95% CI 0.94–0.98) for the stem. No demographic factors or covariates were found to significantly affect the implant survivorship.


As there was no superior probability of survival, and there have been concerns on putative local and systemic toxicity of metal debris, the use of second-generation metal-on-metal articulations for primary THR remains moot.

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