Coxa has several ongoing research projects

22.03.2018 — News

During 2017, our research projects progressed as planned on many fronts. At the end of the year, we launched several new projects, some of which have already influenced Coxa’s daily practices.

During the last few months, we have started two completely new lines of research. In the first line of research, we delve into revision knee replacement: we study the overall effectiveness of these procedures, results of secondary patellar resurfacing as well as the outcome of mobilisation under anaesthesia. Three medical students (Hanna Tevalin, Anniina Tandefelt and Katri Rasa) work in this project under the supervision of the undersigned and orthopaedic surgeon Mika Niemeläinen. In the second new project, we are studying the incidence of dislocations after total hip replacements performed at Coxa and the factors influencing it. This project involves two medical students (Oskari Pakarinen and Jaakko Seppänen). All the above medical students will start working at Coxa as medical interns in the summer of 2018.

Of the previous projects, the PNP study continues, with currently over 200 patients recruited for this three-arm randomized controlled trial that compares functional outcome after a recently introduced total knee replacement (Persona) compared to well-documented contemporary knee replacements (PFC and Nexgen). The goal of 240 patients is near. Multiple patient-reported outcome measures are applied in this project to assess the outcome of these three groups with a two year follow-up.

Also, the hip and knee retrieval studies have progressed very well. These studies are conducted in cooperation with the University College London (UCL) and the London Implant Retrieval Centre (LIRC). In the autumn 2017, medical student Anni Rajamäki joined the knee research group, and she will also work as a medical intern at Coxa next summer.

Active collaboration with the Nordic countries is continuing as well. The combined database of NARA, Nordic Arthroplasty Register Association, will be used this year in the doctoral theses of our two researchers, orthopaedic surgeon Mika Niemeläinen and MD Pia Salo.

In the spring 2018, we will participate in two Nordic multicentre studies, in first of which we will evaluate the results of the Continuum cup in primary total hip arthroplasties in the Nordic countries. In the second study, we will investigate what kind of mobilisation restrictions Finnish hospitals use following hip replacement in comparison with hospitals from other Nordic countries. Coxa’s orthopaedic surgeon Perttu Neuvonen and the undersigned are responsible for the implementation of this study in Finland.

During the last year, we have also started two research projects in cooperation with Zimmer Biomet. In connection with the long-term follow-up of patients with a Rotating Hinge Knee (RHK), several patients had a check-up at our clinic in autumn 2017, and a large group of patients from all over Finland who have had a RHK surgery in previous years answered our research surveys. This study is part MD Jake von Hintze‘s doctoral thesis. The preliminary results have been summarised, and it can already be stated that the long-term results of RHK prostheses were good in this demanding patient group in terms of both primary and revision surgeries.

The second study financed by Zimmer Biomet is the recently started Nexel study, with orthopaedic surgeon Pirjo Honkanen as the principal investigator at Coxa. This is an international multicentre study, and Coxa is the only Finnish hospital involved in the study. The study evaluates the results and safety of Nexel, a new elbow joint replacement recently brought into the market.

Antti Eskelinen
Chief Orthopaedic Surgeon & Research Director
Coxa