CoxaPro > Clinical Library > Tervetuloa Clinical Libraryyn > Tranexamic acid in total hip arthroplasty: Mixed treatment comparisons of randomized controlled trials and cohort studies
J Orthop. 2018 Mar; 15(1): 81–88.

Tranexamic acid in total hip arthroplasty: Mixed treatment comparisons of randomized controlled trials and cohort studies

Kannan Sridharana,⁎ and Gowri Sivaramakrishnanb
Hip

Background

The present study is a network meta-analysis of various routes of tranexamic acid (TXA) in patients with total hip arthroplasty (THA).

Methods

Randomized controlled trials and cohort studies evaluating TXA in patients with THA were included. Number of patients requiring blood transfusion was the primary outcome.

Results

Pooled estimate for TXA use against placebo for blood transfusion rate was 0.30 [0.23, 0.39] favoring TXA. Maximum reduction in the risk of blood transfusion was observed with topical plus intra-operative intravenous TXA.

Conclusion

Combined topical and intravenous TXA during surgery may perform better than other modes in patients undergoing THA.


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