The Journal of Arthroplasty, Volume 34, Issue 7, S228 - S231

Matched Cohort Analysis of Total Hip Arthroplasty in Patients With and Without Parkinson’s Disease: Complications, Mortality, Length of Stay, and Hospital Charges

Kleiner, Justin E. et al.


Increased complication rate has been reported in Parkinson’s disease (PD) patients following total hip arthroplasty (THA). However, this has not previously been studied on a national scale. The purpose of this study was to determine whether PD patients had increased cost, complication, mortality, and length of stay following THA using a national database.


The Healthcare Cost and Utilization Project Nationwide Inpatient Sample was evaluated for the years 2000-2014. PD patients were matched 1:3 with non-PD control patients for age, gender, Charlson Comorbidity Index, and year of admission using a propensity score matching procedure. Univariable and multivariable logistic regression were used to determine the relationship between PD and surgical outcomes in the matched cohort.


794,689 THAs were performed from 2000-2014. 4003 patients (0.50%) had comorbid Parkinson’s disease. Before matching, arthroplasty patients with PD were significantly older ( P < .001), more frequently male ( P < .001), and had greater Charlson Comorbidity Index ( P < .001). In the matched cohort, PD was associated with increased length of stay (3.1 vs 2.7 days, P < .001), total hospital charges ($49,061 vs $45,571, P < .001), and in-hospital complication rate (14.6% vs 11.7%, P < .001). There was no difference in-hospital mortality (0.50% vs 0.47%, P = .781).


Matched cohort analysis demonstrated increases in complication rate, length, and cost of hospitalization for THA in patients with PD. However, in-hospital mortality rate in PD patients was not increased. Of note, the elevation in per-episode cost ($3490) may be of concern when considering PD patients for surgery within the evolving “bundled payment” model of care.

Level of Evidence

Prognostic- Level III.

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