Clinical Orthopaedics and Related Research: October 2012 - Volume 470 - Issue 10 - p 2730–2736 doi: 10.1007/s11999-012-2358-8 Symposium: 2011 Musculoskeletal Infection Society

Assessing the Gold Standard: A Review of 253 Two-Stage Revisions for Infected TKA

Mahmud, Tahir, MBBS, FRCS(Tr&Orth)1, a; Lyons, Matthew, C., MBBS, FRACS1; Naudie, Douglas, D., MD, FRCSC1; MacDonald, Steven, J., MD, FRCSC1; McCalden, Richard, W., MD, FRCSC1

Background Periprosthetic joint infection has been the leading cause of failure following TKA surgery. The gold standard for infection control has been a two-staged revision TKA. There have been few reports on mid- to long-term survivorship, functional outcomes, and fate of patients with a failed two-stage revision TKA.


Questions/purposes Therefore, we determined (1) the mid-term survivorship of two-stage revision TKA, (2) the function of patients in whom infection was controlled, and (3) the outcome of patients with a failed two-stage revision due to recurrent infection.


Methods We retrospectively reviewed 239 patients who underwent 253 two-stage revision TKAs for periprosthetic infection. There were 239 patients (253 knees), 104 men and 135 women, with a mean age of 70 ± 10 years at the time of two-stage revision and a mean BMI of 31.53 ± 6.74 kg/m2. During followup, we obtained WOMAC and The Knee Society Clinical Rating Scores and radiographs. The minimum followup was 1 year (median, 4 years; range, 1-17 years).


Results Thirty-three patients experienced a failed two-staged TKA. Sixteen patients experienced failure due to recurrent sepsis. There were 17 failures for aseptic causes.


Conclusion The overall infection-free survivorship for two-stage revision TKA was 85% at 5 years and 78% at 10 years.


Level of Evidence Level IV, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.

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